Carbamic acid, N-(3R)-3-piperidinyl-, phenylmethyl ester
benzyl N-[(3R)-3-piperidyl]carbamate
CAS: 478646-32-1
Molecular Formula: C13H18N2O2
Carbamic acid, N-(3R)-3-piperidinyl-, phenylmethyl ester - Names and Identifiers
| Name | benzyl N-[(3R)-3-piperidyl]carbamate |
| Synonyms | (R)-3-(Cbz-aMino)piperidine (R)-3-N-Cbz-aminopiperidine (R)-3-(Cbz-aMino)piperidi... Benzyl (R)-piperidin-3-ylcarbamate (R)-benzyl piperidin-3-ylcarbamate Benzyl (3R)-piperidin-3-ylcarbamate benzyl N-[(3R)-3-piperidyl]carbamate benzyl N-[(3R)-piperidin-3-yl]carbamate CarbaMic acid, (3R)-3-piperidinyl-, phenylMethyl ester Carbamic acid, N-(3R)-3-piperidinyl-, phenylmethyl ester Carbamic acid, N-[(3R)-3-piperidinyl]-, phenylmethyl ester |
| CAS | 478646-32-1 |
| InChI | InChI=1/C13H18N2O2/c16-13(15-12-7-4-8-14-9-12)17-10-11-5-2-1-3-6-11/h1-3,5-6,12,14H,4,7-10H2,(H,15,16)/t12-/m1/s1 |
Carbamic acid, N-(3R)-3-piperidinyl-, phenylmethyl ester - Physico-chemical Properties
| Molecular Formula | C13H18N2O2 |
| Molar Mass | 234.29 |
| Density | 1.13g/cm3 |
| Boling Point | 396.3°C at 760 mmHg |
| Flash Point | 193.5°C |
| Vapor Presure | 1.73E-06mmHg at 25°C |
| Storage Condition | 2-8°C(protect from light) |
| Refractive Index | 1.557 |
Carbamic acid, N-(3R)-3-piperidinyl-, phenylmethyl ester - Risk and Safety
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37 - Wear suitable gloves. |
| HS Code | 29333990 |
Carbamic acid, N-(3R)-3-piperidinyl-, phenylmethyl ester - Introduction
Benzyl N-[(3R)-3-piperidyl]carbamate is an organic compound containing an aminopiperidine ring and a benzyl carbamate group in its chemical structure.
Nature:
benzyl N-[(3R)-3-piperidyl]carbamate has the physical state of a white crystalline solid, its molecular formula is C18H22N2O2, and its relative molecular mass is 298.38g/mol. It has good solubility and is soluble in organic solvents.
Use:
benzyl N-[(3R)-3-piperidyl]carbamate has a wide range of applications in medicinal chemistry. It can be used as a synthetic intermediate for the preparation of a variety of drugs, such as anticancer drugs, antiviral drugs and anti-infective drugs. In addition, it can also be used for the synthesis of ligands, catalysts and protecting groups in organic synthesis reactions.
Preparation Method:
The preparation of benzyl N-[(3R)-3-piperidyl]carbamate is usually obtained by the transesterification of benzyl amine with benzyl N-hydroxypiperidine carboxylate. In practice, benzylamine and benzyl N-hydroxypiperidine carboxylate are reacted under appropriate reaction conditions, and the target product is obtained by crystallization and purification.
Safety Information:
The chemical properties of benzyl N-[(3R)-3-piperidyl]carbamate make it relatively safe under normal conditions of use. However, as with all chemicals, proper handling and safety measures should be followed to avoid contact with skin, inhalation of gases or ingestion. Attention should be paid to protective measures in handling and storage, and proper disposal of waste.
Nature:
benzyl N-[(3R)-3-piperidyl]carbamate has the physical state of a white crystalline solid, its molecular formula is C18H22N2O2, and its relative molecular mass is 298.38g/mol. It has good solubility and is soluble in organic solvents.
Use:
benzyl N-[(3R)-3-piperidyl]carbamate has a wide range of applications in medicinal chemistry. It can be used as a synthetic intermediate for the preparation of a variety of drugs, such as anticancer drugs, antiviral drugs and anti-infective drugs. In addition, it can also be used for the synthesis of ligands, catalysts and protecting groups in organic synthesis reactions.
Preparation Method:
The preparation of benzyl N-[(3R)-3-piperidyl]carbamate is usually obtained by the transesterification of benzyl amine with benzyl N-hydroxypiperidine carboxylate. In practice, benzylamine and benzyl N-hydroxypiperidine carboxylate are reacted under appropriate reaction conditions, and the target product is obtained by crystallization and purification.
Safety Information:
The chemical properties of benzyl N-[(3R)-3-piperidyl]carbamate make it relatively safe under normal conditions of use. However, as with all chemicals, proper handling and safety measures should be followed to avoid contact with skin, inhalation of gases or ingestion. Attention should be paid to protective measures in handling and storage, and proper disposal of waste.
Last Update：2024-04-09 20:52:54
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